Partial Least Square (PLS) regression

I need help conducting PLS regression for a dataset. If you could provide step-by-step and interpretation of the results it would be great.

#Analysis 1 --- Unrestricted model
#1)run PLS regression for 42 predictors (CG_left..., CG_right.., IFO_left..., IFO_right..., UF_left.. UF_right..) and 2 outcomes (anxiety, depression)

#2)run PLS regression for 14 predictors (AR_left_.., AR_right_..) and 2 outcomes: (anxiety, depression)

# Analysis 2 --- Restricted model
#1) run PLS regression for 42 predictors (CG_left..., CG_right.., IFO_left..., IFO_right..., UF_left.. UF_right..) and 2 outcomes (anxiety, depression) while controlling for (EDSS, relapse_rate, age_mri,sex)

#2)run PLS regression for14 predictors (AR_left_.., AR_right_..) and 2 outcomes: (anxiety, depression) , while controlling for (EDSS, relapse_rate, age_mri,sex)