Mutations in CTNNB1 gene encoding catenin in hepatocellular carcinoma
Budget: £10 – £30 GBP
The incidence of hepatocellular carcinoma (HCC) has risen over last decades
worldwide. Significant number of the HCC cases are associated with stabilizing
mutations in the gene encoding catenin.
In this essay you should describe the molecular pathways catenin is involved in
and how stabilizing mutations in the CTNNB1 gene leads to mis-regulation of these
pathways resulting in HCC development and progression.
1. Description of the molecular process the catenin protein is involved in
normal liver development and homeostasis.
2. The molecular nature of the defects in the catenin gene in the HCC and
resulting alterations in the molecular process it is involved in.
3. A description of changes in the cellular physiology resulted from the defects.
4. A description of the clinical manifestations of the HCC and the treatment
options.
worldwide. Significant number of the HCC cases are associated with stabilizing
mutations in the gene encoding catenin.
In this essay you should describe the molecular pathways catenin is involved in
and how stabilizing mutations in the CTNNB1 gene leads to mis-regulation of these
pathways resulting in HCC development and progression.
1. Description of the molecular process the catenin protein is involved in
normal liver development and homeostasis.
2. The molecular nature of the defects in the catenin gene in the HCC and
resulting alterations in the molecular process it is involved in.
3. A description of changes in the cellular physiology resulted from the defects.
4. A description of the clinical manifestations of the HCC and the treatment
options.