Molecular Impairment in Amyotrophic Lateral Sclerosis (ALS)

Write about the molecular impairments that are present in the Amyotrophic Lateral Sclerosis (ALS) disease. You must emphasize how mutations in ALS affects the cell function!

Use the following sketch for guidance in your writing.

A. Impaired DNA repair in ALS
B. Altered RNA metabolism in ALS
B. Axonal transport impairment in ALS
C. Endoplasmic Reticulum Stress in ALS
D. Mitochondrial Dysfunction and oxidative stress in ALS
E. Proteosome and autophagy impairment in ALS (must include mitophagy too when speaking of autophagy)

You must write an explanation of each impairment in Amyotrophic Lateral Sclerosis (ALS). In the explication you must mention data (findings) obtained that prove that this impairments occur in Amyotrophic Lateral Sclerosis disease. Remember to cite correctly all the data in APA format.

You don't need to make an introduction in the work explaining the definition of Amyotrophic Lateral Sclerosis, or mention the genes associated. I already have that. I only what the Molecular Impairment in Amyotrophic Lateral Sclerosis (ALS) section which is the sketch above.

Instructions:
- APA format 7 edition
- single space
- you must write at least two good paragraphs of each impairments (A-E)
- Number of pages: approximately 4-5 pages of writing (this do not include the references pages)
- You do not have to make a cover. You can start writing about the impairments in ALS in the first page.
- Remember the reference list in APA at the end.
- In case of any question you can contact me in the chat.