Rituximab. Michanism of action and trials -- 2

2000 word ( not include the references)
Use Pubmed for search
No paragrism
Short paragraph about monoclonal antibodies.
Discovery of Rituximab.
Rituximab components and mechanisms of actions.
Preclinical trials.
In Vitro and in vivo trials and trials in animals.
Phase 1,2,3 and 4 trials.
Approvals in Europe and FDA.
Today uses
Side effects