python dataframe

I need python code that queries a two-level column dataframe and creates a new dataframe with the data that meets the query criteria. The purpose of the project is to backest the performance of a stock portfolio. The query needs to be done on a row by row basis. If interested, I'll provide you with a sample spreadsheet (input data) as well as what I want the resulting dataframe to look like plus additional details about the query. I'm guessing that a python expert should be able to do this in an hour or two. Thanks.