Rapid Review Protocol (2000 word):Dextrose 50% versus dextrose 10% or dextrose titration for the treatment of out-of-hospital hypoglycemia.
Budget: £20 – £250 GBP
• Title
• Background to the review that provides a clear rational for the rapid review question
• Review question
• Review objectives
• REVIEW METHODS
o A critical analysis of rapid review methods based on the currentl literature
o PICO/ PICo / or other approriate mnemonic for structuring your search
o Search strategy to include the databases to be search and the priliminary search terms (a completed search in a database may be included as appendix - search terms and number of results only, not titles/ abstracts)
o Inclusion and exclusion criteria to include types of study design and nny limits to be explained and a rational provided.
o Methods for risk of bias assessment and data extraction
o Methods for data analysis and synthesis.
o References in the appropriate format
o Appendices
Remember that a rapid review aims to answer a review question in an optimum period and therefore makes use of efficiencies such as:
1. Limiting the number of databases searched
2. Limiting the duration of the search, e.g 10 year publication period.
3. Limiting the language to English; using geographical limits e.g., only UK or UK and Europe
4. Reducing the use of 'double' screening, selection, appraisal and data extraction. Where you do this you should indicate that there will be an audit process of a certain percentage of the above processes.
5. The search and appraisal of evidence in a staged approach, starting with evidence based guidelines and systematic reviews, before moving to individual studies of the appropriate design.
6. Producing a narrative synthesis rather than a meta-analysis for effectiveness reviews; mapping themes rather than meta-ethnography or meta-aggregation for qualitative reviews.
Protocol Structure
Title of your rapid review
1. Background to the review – what is the issue; why is is important to paramedic practice. This might include the frequency of an event, the nature of the injury/ health issue, the epidemiology, the different approaches to dealing with a problem/ injury
2. The objective of the review and the specific review question(s)
3. The inclusion criterial for studies – this should be guided by your PICO (or variant) and the type of question you are asking e.g., an effectiveness question, an experience question.
4. Search strategy, terms used and databases/ journals searched; date and language limits; published/ unpublished studies
5. Assessment criteria, which tools are you going to use to guide the assessment of the quality of the literature.
6. How are you going to synthesise the findings? Narratively, or statistically (meta-analysis for quant reviews)
Use the PICO format when investigating the effectiveness of an intervention:
Population (who): children
Population (condition / location): pre-hospital
Intervention: intubation
Comparison: -
Outcome: patient safety
Https://www.cambridge.org/core/journals/prehospital-and-disaster-medicine/article/abs/dextrose-50-versus-dextrose-10-or-dextrose-titration-for-the-treatment-of-outofhospital-hypoglycemia-a-systematic-review/D953B0449CA9F020370748C9F3C50A19
Https://ajp.paramedics.org/index.php/ajp/article/view/177
Https://www.meta.org/papers/dextrose-10-or-50-in-the-treatment-of/15983093
Https://www.aliem.com/d50-vs-d10-severe-hypoglycemia-emergency-department/
Https://www.semanticscholar.org/paper/P088%3A-Dextrose-50-versus-dextrose-10-or-dextrose-of-Hurtubise-Greene/aba8e00ce0daf6a2046acd0a9db5ec58024f1d10
Https://cdn.dal.ca/content/dam/dalhousie/pdf/faculty/medicine/departments/department-sites/emergency/emsfiles/EMSRDAY/mhurtubise%20EMSRD1.pdf
Https://journals.sagepub.com/doi/abs/10.1177/0897190019889444
• Background to the review that provides a clear rational for the rapid review question
• Review question
• Review objectives
• REVIEW METHODS
o A critical analysis of rapid review methods based on the currentl literature
o PICO/ PICo / or other approriate mnemonic for structuring your search
o Search strategy to include the databases to be search and the priliminary search terms (a completed search in a database may be included as appendix - search terms and number of results only, not titles/ abstracts)
o Inclusion and exclusion criteria to include types of study design and nny limits to be explained and a rational provided.
o Methods for risk of bias assessment and data extraction
o Methods for data analysis and synthesis.
o References in the appropriate format
o Appendices
Remember that a rapid review aims to answer a review question in an optimum period and therefore makes use of efficiencies such as:
1. Limiting the number of databases searched
2. Limiting the duration of the search, e.g 10 year publication period.
3. Limiting the language to English; using geographical limits e.g., only UK or UK and Europe
4. Reducing the use of 'double' screening, selection, appraisal and data extraction. Where you do this you should indicate that there will be an audit process of a certain percentage of the above processes.
5. The search and appraisal of evidence in a staged approach, starting with evidence based guidelines and systematic reviews, before moving to individual studies of the appropriate design.
6. Producing a narrative synthesis rather than a meta-analysis for effectiveness reviews; mapping themes rather than meta-ethnography or meta-aggregation for qualitative reviews.
Protocol Structure
Title of your rapid review
1. Background to the review – what is the issue; why is is important to paramedic practice. This might include the frequency of an event, the nature of the injury/ health issue, the epidemiology, the different approaches to dealing with a problem/ injury
2. The objective of the review and the specific review question(s)
3. The inclusion criterial for studies – this should be guided by your PICO (or variant) and the type of question you are asking e.g., an effectiveness question, an experience question.
4. Search strategy, terms used and databases/ journals searched; date and language limits; published/ unpublished studies
5. Assessment criteria, which tools are you going to use to guide the assessment of the quality of the literature.
6. How are you going to synthesise the findings? Narratively, or statistically (meta-analysis for quant reviews)
Use the PICO format when investigating the effectiveness of an intervention:
Population (who): children
Population (condition / location): pre-hospital
Intervention: intubation
Comparison: -
Outcome: patient safety
Https://www.cambridge.org/core/journals/prehospital-and-disaster-medicine/article/abs/dextrose-50-versus-dextrose-10-or-dextrose-titration-for-the-treatment-of-outofhospital-hypoglycemia-a-systematic-review/D953B0449CA9F020370748C9F3C50A19
Https://ajp.paramedics.org/index.php/ajp/article/view/177
Https://www.meta.org/papers/dextrose-10-or-50-in-the-treatment-of/15983093
Https://www.aliem.com/d50-vs-d10-severe-hypoglycemia-emergency-department/
Https://www.semanticscholar.org/paper/P088%3A-Dextrose-50-versus-dextrose-10-or-dextrose-of-Hurtubise-Greene/aba8e00ce0daf6a2046acd0a9db5ec58024f1d10
Https://cdn.dal.ca/content/dam/dalhousie/pdf/faculty/medicine/departments/department-sites/emergency/emsfiles/EMSRDAY/mhurtubise%20EMSRD1.pdf
Https://journals.sagepub.com/doi/abs/10.1177/0897190019889444