Meta-Analysis on Osteoarthritis Treatments Effectiveness -- 2

I am preparing a full meta-analysis to quantify and compare the effectiveness of current osteoarthritis treatments. The end goal is published article to a peer-reviewed journal, complete with transparent methodology and publication-quality figures. Scope of work • Draft a brief protocol (PRISMA-aligned) and register it in PROSPERO before we begin. • Conduct a comprehensive literature search across MEDLINE, Embase, Cochrane Library, and any other database you believe will improve coverage. • Screen studies against predefined inclusion criteria, extract the required outcome data, and assess risk of bias. • Pool effect sizes using random- or fixed-effects models as appropriate. I am happy for you to work in R (meta/metafor), Stata, or RevMan—just keep the code or log files reproducible. • Provide forest plots, funnel plots, heterogeneity statistics (I², τ²), and, if data allow, a meta-regression or subgroup analysis. • Write a concise results and discussion section that situates the findings within current osteoarthritis guidelines and highlights clinical implications. Acceptance criteria 1. A registered protocol number and the full search strategy. 2. Cleaned data-extraction sheet (CSV or Excel). 3. Annotated analysis script or RevMan file producing identical figures. 4. Draft manuscript (≈5000 words) with tables and figures ready for journal submission. If you have published meta-analyses on musculoskeletal disorders—or can point me to similar work in your portfolio—please mention it when you respond.