Equine Curcumin Clinical Study Design

I am organizing a controlled clinical study to measure how an oral curcumin supplement influences both recovery and bioavailability in a herd of more than 20 horses. I need a veterinary research professional who can shape the entire protocol from start to finish.

Key tasks
• Draft a scientifically sound study design outlining objectives, hypotheses, inclusion/exclusion criteria, treatment groups, dosage schedule, and wash-out periods.
• Define clear metrics for recovery (e.g., muscle enzyme profiles, lameness scores, heart-rate variability) and bioavailability (e.g., plasma curcumin concentration, AUC, Tmax).
• Create a sampling timeline and specify required laboratory assays.
• Prepare all study documentation: informed consent forms for owners, animal ethics committee application, SOPs for dosing, sample handling, data collection sheets, and adverse event reporting.
• Recommend statistical methods and power calculations suitable for the cohort size (>20 horses).
• Outline practical logistics—stable requirements, feed controls, randomization, blinded assessments—and identify any specialized equipment.
• Deliver a concise plan for data analysis and final reporting templates.

I will supply background literature on equine curcumin studies and have access to a cooperating equine clinic. Your deliverable will be a complete, ready-to-submit protocol package (Word + PDF) that the clinic staff can follow without additional clarification.

Veterinary clinical research experience—preferably in equine nutrition or musculoskeletal recovery—is essential. Familiarity with GLP guidelines and statistical software such as SAS or R will be highly valued.