Home Audio Setup for Instruments

I need assistance connecting various instruments to a mixer and sound system for a home setup. The primary use will be casual listening.

Instruments include:
- Guitar
- Keyboard
- Microphone
- Alesis drums

Ideal Skills and Experience:
- Experience with audio mixers and sound systems
- Knowledge of connecting multiple instruments
- Familiarity with home audio setups
- Ability to ensure quality sound for casual listening

Please provide a solution that is user-friendly and effective for home use.