Technical Peptide Chemistry Figure Design

The proposed translational pipeline for peptide‑based AD therapeutics, beginning with AI‑enabled target identification and de novo sequence generation, followed by medicinal chemistry optimization and stability engineering, scalable synthesis (including fast‑flow platforms), BBB‑competent delivery strategies, and finally clinical trial design and regulatory evaluation. Feedback arrows indicate that data from in vitro assays, in vivo models, and early‑phase trials iteratively refine upstream AI models and design criteria.